ABSENCE OF FERTILITY EFFECTS IN PARACETAMOL AND IBUPROFEN PRE-TREATED MICE

Authors

  • Cristina Abreu de Araújo
  • Carlos Eduardo Tadokoro
  • Fernanda de Oliveira Busato
  • Roberta Miranda de Araújo Mendes
  • Flávio Curbani
  • David N. Olivieri
  • Alessandro Coutinho Ramos

Keywords:

over-the-counter medications; pain relievers; pregnancy; implantation

Abstract

Mice treatment with anti-inflammatory medications can be a routine procedure in mouse facilities. In some cases, these animals can be used to perform breeding pairs, and nothing is known about any deleterious pre-treatment effect on their fertility. Our goal was to evaluate anti-fertility effects of paracetamol and ibuprofen if administered before mating. Female Swiss mice were treated either with paracetamol or with ibuprofen, prior to mating. After mating, the number of pregnant females, fetuses, and spontaneous fetal reabsorptions were counted. Neither pre-mating treatments produced measurable differences in the proportions of pregnant females, number of fetuses, or fetal reabsorptions when compared to the non-treated control or vehicle-treated (PBS) groups. Thus, continuous treatments of either paracetamol or ibuprofen may not induce permanent physiological changes that interfere with the female fertility if the treatments are interrupted during the mating period.

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Published

2022-12-20

How to Cite

Cristina Abreu de Araújo, Carlos Eduardo Tadokoro, Fernanda de Oliveira Busato, Roberta Miranda de Araújo Mendes, Flávio Curbani, David N. Olivieri, & Alessandro Coutinho Ramos. (2022). ABSENCE OF FERTILITY EFFECTS IN PARACETAMOL AND IBUPROFEN PRE-TREATED MICE. InterSciencePlace, 17(4). Retrieved from https://www.interscienceplace.org/index.php/isp/article/view/522

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